Bioactive Small Molecules
Selleck Chemical LLC Remdesivir S8932-5MG
Remdesivir (GS-5734) a monophosphoramidate prodrug of an adenosine analog is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses including Ebola and CoV
Medchemexpress LLC N-((Benzyloxy)carbonyl)-O-(tert-butyl)-L-threonine | 16966-09-9 | 99.9% | 309.36 | 100 G
N-((Benzyloxy)carbonyl)-O-(tert-butyl)-L-threonine is a threonine derivative. Amino acids and amino acid derivatives are commercially used as ergogenic supplements for various applications.
- Influences the secretion of anabolic hormones
- Provides fuel supply during exercise
- Enhances mental performance during stress-related tasks
- Helps prevent exercise-induced muscle damage
Medchemexpress LLC Cefixime trihydrate | 125110-14-7 | 99.8% | 100 MG
Cefixime trihydrate is an antibiotic and a third-generation cephalosporin, useful for the treatment of a number of bacterial infections. It is for research use only and not for patient use.
- Shows great antibacterial activity against clinical isolates of *Salmonella typhi*.
- Active against β-lactamase producing Amoxicillin-resistant strains.
- Active against *Enterobacteriaceae*, such as *Haemophilus influenzae*, and *Neisseria gonorrhoeae*.
- Available in various sizes.
- Purity of 99.8%.
- White to off-white solid appearance.
Cayman Chemical ANTIBODY CGI1746 1mg
A potent, selective inhibitor of BTK (IC50 = 1.9 nM); prevents BCR-mediated B lymphocyte proliferation; reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis
Cayman Chemical ANTIBODY CDKI-73 5mg
An inhibitor of Cdk9/cyclin T1, Cdk1/cyclin B, and Cdk2/cyclin A complexes (Kis = 4, 4, and 3 nM, respectively); selective for these complexes over the Cdk7/cyclin H complex (Ki = 91 nM); cytotoxic to HCT116 cells (GI50 = <10 nM); induces apoptosis in COLO 205, HCT116, HT-29, and KM12 cells at 0.25 or 1 µM; reduces the levels of Bcl-2, cyclin D1, and Mcl-1, as well as decreases the mitochondrial membrane potential, in HCT116 cells at 0.25 µM; decreases tumor volume in an HCT116 mouse xenograft model at 100 mg/kg every three days
Selleck Chemical LLC L 189 S0102-25MG
L 189 is a novel human DNA ligase inhibitor with IC50 of 5 M 9 M and 5 M for hLigI hLigIII and hLigIV respectively L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ) L 189 specifically sensitizes cancer cells to DNA damage
Abcam Indirubin-3'-mono x ime, GSK3beta inhibitor. CDK inhibitor., 5MG
MW 277.28 g/mol, Purity >98%. Potent GSK3β inhibitor (IC₅₀ = 22 nM). CDK inhibitor (IC₅₀ values are 0.1 (Cdk5/p35), 0.18 (Cdk1/cyclin B), 0.25 (Cdk2/cyclin E), 0.5 (Cdk2/cyclin A) and 3.3 μM (Cdk4/cyclin D1)). Shows reversible antiproliferative effects via G₂/M cell cycle arrest. Prevents tau phosphorylation. Shows neuroprotective effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen S14161 (5 mg)
Chemical. CAS: 883046-50-2. Formula: C17H14FNO4. MW: 315.3. Potent antileukemia and antimyeloma compound. Apoptosis inducer. Delays tumor growth. Cyclin D2 promoter transactivation inhibitor. Inhibitor of pan-Class I PI3K isoforms.
Cayman Chemical Acetyl Resveratrol 5g
A triacetylated derivative of resveratrol that has diverse biological activities; inhibits the growth of LNCaP, DU145, and PC3M prostate cancer cells (IC50s = 10.5, 14.2, and 26.8 μM, respectively); induces cytotoxicity in ALL-5 acute lymphoblastic leukemia cells (IC50 = 3.4 μM) and induces cell cycle arrest at the G1 phase at 17 μM; increases survival in mice exposed to total body γ-irradiation at 10 mg/kg prior to irradiation
AdipoGen Andrastin A (1 mg)
Chemical. CAS: 174232-42-9. Formula: C28H38O7. MW: 486.6. Isolated from Aspergillus fumigatus. Mycotoxin. Protein farnesyltransferase (PFTase) inhibitor. Anti-cancer compound. Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells.
Cayman Chemical ANTIBODY AdefovIr 10mg
An active metabolite of adefovir dipivoxil; formed from adefovir dipivoxil by CES2; inhibits cytopathogenicity induced by HSV-1 and HSV-2 (EC50 = 7 UG/ml for both in E6SM cells), HIV-1 and HIV-2 (EC50s = 1.8 and 2.5 UG/ml, respectively, in CEM cells), and VZV (EC50 = 10 UG/ml in human embryonic lung fibroblasts); reduces increases in lymph node viral DNA and serum IgG levels in a mouse model of AIDS induced by infection with LP-BM5 at 50 mg/kg; inhibits tumor growth induced by MSV infection in mice at 50 mg/kg
Medchemexpress LLC GSK1016790A | 942206-85-1 | 99.9% | 655.61 | 5 MG
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. It can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells.
- Elicits Ca2+ influx in mouse and human TRPV4-expressing human embryonic kidney (HEK) cells (EC50 values of 18 and 2.1 nM, respectively).
- Evokes a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM.
- Treatment elicits a rapid elevation of intracellular Ca2+ in a subset of neurons.
- Produces a dose-dependent inhibitory effect on whole gut transit time in mice.
- Significantly inhibits electrical field stimulation (EFS)-induced twitch contractions in isolated mouse colon strips in a concentration-dependent manner.
