Bioactive Small Molecules
Medchemexpress LLC HY-13631A 500mg , Exatecan (mesylate) CAS:169869-90-3 Purity:>98%
HY-13631A 500mg Exatecan (mesylate) CAS: 169869-90-3 Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC TPO/Thyroid Peroxida 20ug | 20ug
Thyroid Peroxidase (TPO) orchestrates iodination and coupling within thyroglobulin leading to the synthesis of thyroid hormones T(3) and T(4) TPO/Thyroid Peroxidase Protein Mouse (HEK293 His) is the recombinant mouse-derived TPO/Thyroid Peroxidase protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC HY-100218A 50mg , RSL3 CAS:1219810-16-8 Purity:>98%
HY-100218A 50mg RSL3 CAS: 1219810-16-8 RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC CD276/B7-H3 4Ig /B7 1mg
Recombinant human CD276/B7-H3 (4Ig) protein is expressed in HEK293 cells and supplied as a C-terminal His-tagged, lyophilized material. It is glycosylated and provided at high purity for use in immune regulation, tumor biology, and assay development where mammalian post-translational modification is required.
- Mammalian-expressed, glycosylated protein suitable for functional and binding assays.
- C-terminal His tag enables detection and affinity purification.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Multiple vial sizes available from 5 μg to 1 mg to fit assay scale.
- Lyophilized formulation for improved stability and handling.
- Store at -20°C; aliquot and keep at -20°C or -80°C for long-term storage.
- Not recommended to reconstitute below 100 μg/mL in ddH2O to maintain activity.
Medchemexpress LLC Methyldopate | 6014-30-8 | 98.0% | 1 ML
Methyldopate is an ethyl ester proagent of α-Methyldopa (α-MD; HY-B0225) that acts as an α-adrenergic agonist, selective for α2-adrenergic receptors. It has the potential for severe hypertension research and is suitable for laboratory centrifugation and storage. The product is provided as a solid solution.
- Ethyl ester proagent of α-Methyldopa
- Acts as an α-adrenergic agonist
- Selective for α2-adrenergic receptors
- Potential for severe hypertension research
- Suitable for laboratory centrifugation and storage
Cayman Chemical 2-NP-AOZ, Purity: ≥95%, CAS: 19687-73-1, 50 mg
A derivatized metabolite of furazolidone; formed from tissue-bound AOZ after acid hydrolysis and derivatization with o-NBA; has been used as a marker of furazolidone use in pigs
Enzo Life Sciences 1-Azakenpaullone (1mg). CAS: 676596-65-9
Analog of kenpaullone (BML-EI310) acting as a potent and ATP-competitive inhibitor of GSK-3β (IC50=18nM). Displays ~100-200 fold greater selectivity on GSK-3β than over CDK1/cyclin B and CDK5/p25 (IC50=2.0µM and 4.2µM, respectively). Alternative name: 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 1-AKP. Purity: ≥95% (HPLC, TLC). Solubility: Soluble in DMSO; insoluble in water. Long Term Storage: -20°C.
AdipoGen Nexturastat A (1 mg)
Chemical. CAS: 1403783-31-2. Formula: C19H23N3O3. MW: 341.4. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5.02nM). Displays high selectivity over all other HDACs (IC50=3-10µM). Suppresses cell proliferation and promotes apoptosis in B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78. Dose-dependently induces hyperacetylation of alpha-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation. Induces cell cycle arrest in G1. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
AdipoGen Josamycin Solution (in acetone) (1 ml)
Chemical. CAS: 16846-24-5. Formula: C42H69NO15. MW: 827.99. Josamycin is a member of the leucomycin family of macrolide antibiotics produced by Streptomyces kitasatoensis. It is an antimicrobial against a wide variety of pathogens. It has activity against Gram-positive an Gram-negative bacteria. The mechanism of action is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, inhibiting peptidyltransferase and ribosomal translocation, thereby inhibiting translocation of peptidyl tRNA. Josamycin may overcome anticancer drug resistance by inhibiting the binding of vinblastine or cyclosporin A to P-glycoprotein (Pgp). It is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics and immunomodulatory effects.
Selleck Chemical LLC Cirtuvivint E2668-5MG
Cirtuvivint (SM08502) is a potent and orally active inhibitor of CDC-like kinase (CLK) and a DYRK (dual-specificity tyrosine kinase) that targets mRNA splicing and is optimized for Wnt pathway inhibition Cirtuvivint inhibits serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupts spliceosome activity Cirtuvivint can be used for solid tumor research
Cayman Chemical Physcion, Purity: ≥98%, CAS: 521-61-9, 10 mg
A natural anthraquinone that has been reported to have laxative and anti-inflammatory actions, inhibit kinases and tyrosinase, and have cytotoxicity against cancer cells; inhibits 6-PGD (IC50 = 38.5 µM), decreasing cell proliferation and tumor growth in mice
Medchemexpress LLC Incensole | 22419-74-5 | 5 MG
Incensole is a 14-membered diterpenoid isolated from frankincense essential oils and resins. It exhibits anti-inflammatory and anti-depression activities by activating ion channels in the brain to alleviate anxiety or depression.
- Activator of TRPV3 channels
- Demonstrated anti-inflammatory activity
- Exhibits anti-depression activity
- Activates ion channels in the brain
- Isolated from frankincense
![Medchemexpress LLC Rel-2-[[[(1-methylethyl)amino]carbonyl]amino]-N-[2-[[(1R,2S)-2-[[4-(methylthio)benzoyl]amino] | 445479-97-0 | 99.3% | 593.66 g/mol | C28H34F3N5O4S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245236.png-250.jpg)
Medchemexpress LLC Rel-2-[[[(1-methylethyl)amino]carbonyl]amino]-N-[2-[[(1R,2S)-2-[[4-(methylthio)benzoyl]amino] | 445479-97-0 | 99.3% | 593.66 g/mol | C28H34F3N5O4S | 10 MG
A potent, selective small-molecule antagonist of the chemokine receptor CCR2 intended for research use. It displays high binding affinity (binding IC50 ≈ 5.1 nM) and functional antagonism in calcium flux and chemotaxis assays. The compound is supplied as a white to off-white solid with high purity and is readily soluble in DMSO for preparation of stock solutions.
- High binding affinity to CCR2 (binding IC50 ≈ 5.1 nM).
- Exhibits functional antagonism in calcium flux and chemotaxis assays (calcium flux IC50 ≈ 18 nM; chemotaxis IC50 ≈ 1 nM).
- High purity as supplied.
- Suitable for in vitro and in vivo pharmacology studies.
- White to off-white solid, readily soluble in DMSO.
- Stable under recommended frozen storage for long-term use.
Selleck Chemical LLC Merestinib dihydrochloride E7462-5MG
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent orally bioavailable c-Met inhibitor (Ki 2 nM) with anti-tumor activities Merestinib dihydrochloride also has potent activity against MST1R (IC50 11 nM) FLT3 (IC50 7 nM) AXL (IC50 2 nM) MERTK (IC50 10 nM) TEK (IC50 63 nM) ROS1 DDR1/2 (IC50 0 1/7 nM) and MKNK1/2 (IC50 7 nM)
Selleck Chemical LLC Enalapril E4900-1G
Enalapril(Eletriptan Amprace Vaseretic) is an inhibitor of angiotensin-converting enzyme (ACE) primarily used to treat hypertension heart failure and asymptomatic left ventricular dysfunction It also attenuates frailty in aging mice